A choropleth of the United States showing rate of colorectal cancer in people under 50, 2018-2022. In the U.S. overall, the rate is 9.2 cases for every 100k people. Rates are lowest in the west and highest in the Midwest and South. The state with the lowest rate is Nevada, at 7.6 cases per 100k people, and the state with the highest rate is Kentucky, at 11.4 cases per 100k people.