A table showing the top 10 U.S. cities that saw the greatest population losses from 2021 to 2022. The table includes the 2021 population, 2022 population and the percent change in population from 2021 to 2022 for cities with over 50,000 residents. Jackson, Miss. saw the greatest decline at 2.5%. Three California cities — Livermore, Union City and San Leandro were also on the list.