| Round 1 Pick | Team | Player, POS | College | Draft O/U Prop |
|---|---|---|---|---|
| 1 | Cincinnati Bengals | Joe Burrow, QB | LSU | Consensus No. 1 |
| 2 | Washington Redskins | Chase Young, DE | Ohio State | 2.5 |
| 3 | Detroit Lions | Jeff Okudah, CB | Ohio State | 4.5 (U-120) |
| 4 | New York Giants | Andrew Thomas, OT | Georgia | 10.5 (Over -120) |
| 5 | Miami Dolphins | Tua Tagovailoa, QB | Alabama | 4.5 (Over -250) |
| 6 | Los Angeles Chargers | Justin Herbert, QB | Oregon | 5.5 (Over -125) |
| 7 | Carolina Panthers | Derrick Brown, DT | Auburn | 8.5 (Under -120) |
| 8 | Arizona Cardinals | Isaiah Simmons, LB | Clemson | 6.5 (Under -125) |
| 9 | Jacksonville Jaguars | CJ Henderson, CB | Florida | |
| 10 | Cleveland Browns | Jedrick Wills, OT | Alabama | 8.5 (Under -150) |
| 11 | New York Jets | Mekhi Becton, OT | Louisville | 9.5 (-110) |
| 12 | Las Vegas Raiders | Henry Ruggs, WR | Alabama | 14.5 (Under -120) |
| 13 | Tampa Bay Buccaneers | Tristan Wirfs, OT | Iowa | 8.5 (Under -150) |
| 14 | San Francisco 49ers | Javon Kinlaw, DT | South Carolina | 13.5 (-110) |
| 15 | Denver Broncos | Jerry Jeudy, WR | Alabama | 12.5 (Under -175) |
| 16 | Atlanta Falcons | A.J. Terrell, CB | Clemson | Yes -270 Round 1 |
| 17 | Dallas Cowboys | CeeDee Lamb, WR | Oklahoma State | 12.5 (Under -140) |
| 18 | Miami Dolphins | Austin Jackson, OT | USC | |
| 19 | Las Vegas Raiders | Damon Arnette, CB | Ohio State | |
| 20 | Jacksonville Jaguars | K'Lavon Chaisson, LB | LSU | 16.5 (Over -135) |
