Exercise trials referencing post-exertional malaise (PEM)
Exercise-related clinical trials for Long COVID registered in ClinicalTrials.gov as of November 2025, organized by the year they were posted.
This column chart shows exercise-related trials for Long COVID registered in the ClincialTrials.gov database, sorted according to whether or not their descriptions reference post-exertional malaise (PEM). There were 0 trials registered in 2020, then close to 20 in 2021, over 30 each year in 2022 and 2023, and fewer in 2024 and 2025. The vast majority of trials do not reference PEM (shown in purple), but the share of trials that do (shown in yellow) is larger in 2025 (close to half).
