| Chicago | Pharmaceuticals ($2,789 million) | Mixed freight ($669 million) | Machinery ($542 million) |
| Detroit | Motorized vehicles ($3,451 million) | Pharmaceuticals ($626 million) | Machinery ($435 million) |
| Ft. Wayne | Mixed freight ($467 million) | Base metals ($314 million) | Pharmaceuticals ($264 million) |
| Columbus | Pharmaceuticals ($589 million) | Motorized vehicles ($303 million) | Animal feed ($248 million) |
| Kentucky | Pharmaceuticals ($1,266 million) | Mixed freight ($1,143 million) | Motorized vehicles ($374 million) |
| Louisville | Mixed freight ($876 million) | Pharmaceuticals ($425 million) | Motorized vehicles ($251 million) |
| Nashville | Motorized vehicles ($1,651 million) | Mixed freight ($464 million) | Printed prods. ($208 million) |
| Dallas | Pharmaceuticals ($1,000 million) | Transport equip. ($858 million) | Motorized vehicles ($403 million) |
| Laredo | Machinery ($1,672 million) | Motorized vehicles ($721 million) | Electronics ($126 million) |
