| Role | Pitcher | IP | ERA | WHIP | K/9 |
|---|---|---|---|---|---|
| 1 | Jake Peavy | 1,342 | 3.29 | 1.19 | 9.0 |
| 2 | Yu Darvish | 579 | 3.79 | 1.09 | 9.6 |
| 3 | Blake Snell | 436 | 3.15 | 1.23 | 11.9 |
| 4 | Joe Musgrove | 559 | 3.20 | 1.11 | 9.4 |
| 5 | Tyson Ross | 645 | 3.40 | 1.26 | 8.9 |
| CL | Trevor Hoffman | 479 | 2.87 | 1.06 | 8.9 |
| RP | Heath Bell | 374 | 2.53 | 1.12 | 9.4 |
| RP | Mike Adams | 217 | 1.66 | 0.90 | 10.0 |
| RP | Luke Gregerson | 347 | 2.88 | 1.09 | 9.1 |
| RP | Craig Stammen | 394 | 3.36 | 1.14 | 8.5 |
| RP | Kirby Yates | 183 | 2.55 | 1.00 | 14.1 |
| RP | Brad Hand | 213 | 2.66 | 1.04 | 11.8 |
| RP | Scott Linebrink | 339 | 2.73 | 1.15 | 7.9 |