During the study period, there were a total of 329,119 asthma-related ED visits reported for North Carolina that met the inclusion criteria. Overall, the statewide age-adjusted, asthma-related ED visit rate during the study period (2010–2014) was 66.2 per 10,000 persons. Overwhelmingly, the majority of asthma-related ED visits were from rural counties (91.2%). Among age groups, the 45 to 64 years group had the highest percentage of total asthma ED visits (22.6%). However, the highest age-specific age group was the 0–4 years group, with an average rate of 196.0 (per 10,000 persons/year).