| Role | Pitcher | IP | ERA | WHIP | K/9 |
|---|---|---|---|---|---|
| 1 | Randy Johnson | 1,358 | 2.90 | 1.08 | 11.4 |
| 2 | Brandon Webb | 1,319 | 3.27 | 1.24 | 7.3 |
| 3 | Curt Schilling | 781 | 3.14 | 1.04 | 10.1 |
| 4 | Zac Gallen | 779 | 3.32 | 1.13 | 9.7 |
| 5 | Zack Greinke | 714 | 3.40 | 1.09 | 8.6 |
| CL | José Valverde | 260 | 3.29 | 1.17 | 11.5 |
| RP | Byung-Hyun Kim | 298 | 3.32 | 1.18 | 11.3 |
| RP | Brad Ziegler | 357 | 2.57 | 1.16 | 5.8 |
| RP | Archie Bradley | 404 | 3.96 | 1.38 | 10.0 |
| RP | J.J. Putz | 160 | 2.81 | 1.09 | 10.0 |
| RP | Andrew Chafin | 306 | 3.74 | 1.33 | 10.1 |
| RP | Daniel Hudson | 477 | 3.88 | 1.23 | 7.7 |
| RP | Joe Mantiply | 200 | 3.77 | 1.24 | 8.2 |